Cortana is "Disabled due to your combination of region and language settings not being supported", but my region is set to United States and my language is English (United States). I have restarted my phone several times. I also checked that my speech setting was set to female which I heard could help, but the problem still has not resolved itself. Any suggestions would be much appreciated!
Check your languages page, and make sure the US English is listed on top. (tap & hold > move up)
First revert the changes. Next step, change language ( US or UK) then reboot and then change region (match phone language) and then again reboot. I did like this myself and succeeded.
Turn on Location services from Settings > Location. Location services must be ON to use the Cortana.
- Go to Settings -> Language.
- Make sure that you have added English (United States) and that it is at the top. Else tap and hold English (United States) and select "move up".
- Make sure that it has speech enabled. It might require a download. If it does, tap and hold English (United States) and select "speech options" -> "speech language" -> English (United States) (63 MB).